Cyanobacteria-derived RNA aptamer supports prostate cancer hormone sensitivity

Authors: Carlos D. Cruz-Hernández¹, Bethany Smith¹, Sandrine Billet¹, Manish Thiruvalluvan¹, Gabrielle Gonzales¹, David Underhill², Ekihiro Seki¹,²,³, Shelly C. Lu¹,³, Neil A. Bhowmick¹,²*

1. Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048

2. Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048

3. Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, CA 90048

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Study Overview (Graphical Abstract)

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Cyanobacteria

(S. elongatus)

RNA Aptamer

56merA15

Mechanism
  • • Binds L-Gln
  • • Activates GLS
  • • Depletes L-Gln

Tumor Suppression

Sensitivity Restored